Nevirapine Tablets

Vildagliptin Tablet

Therapeutic Indication

HIV-1 infection (in combination therapy)
Prevention of mother-to-child transmission of HIV
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Nevirapine

Tablet

Nevirapine is a non-nucleoside reverse transcriptase inhibitor (NNRTI) that blocks HIV-1 replication by binding directly to reverse transcriptase. It is used as part of combination antiretroviral therapy.

Speciality Infectious Diseases | HIV Care
Tags NNRTI | Antiretroviral
Strength
  • 400 mg
Packing Size
  • 10 Tablets

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Mechanism

Nevirapine binds directly to HIV-1 reverse transcriptase, causing a conformational change that inhibits its activity and prevents viral replication.

Pharmacokinetics

  • Absorption: Rapid oral absorption
  • Metabolism: Hepatic via CYP3A4
  • Elimination: Renal and fecal excretion
  • Half-life: 25–30 hours

Side Effects

  • Rash
  • Hepatotoxicity
  • Fever
  • Fatigue

Contraindication

  • Severe hepatic impairment
  • Previous hypersensitivity to Nevirapine

Interaction

  • Other CYP3A4 substrates or inducers
  • May reduce efficacy of hormonal contraceptives

Warning and Precautions

  • Monitor liver function regularly
  • Discontinue if severe rash develops
  • Use with caution in patients with hepatitis co-infection

Dosage

As directed by the Physician.