Naproxen Tablets

Mechanism

Naproxen inhibits COX-1 and COX-2 enzymes, reducing prostaglandin synthesis responsible for pain, inflammation, and fever.

Pharmacokinetics

• Absorption: Rapidly absorbed orally; peak plasma levels in 2–4 hours.
• Metabolism: Hepatic metabolism.
• Excretion: Primarily via urine.
• Half-life: ~12–17 hours.

Side Effects

• Gastrointestinal upset (nausea, dyspepsia)
• Heartburn
• Dizziness
• Headache
• Rare: GI bleeding, renal impairment

Contraindication

• Hypersensitivity to naproxen or other NSAIDs
• History of GI bleeding or peptic ulcer
• Severe renal or hepatic impairment
• Pregnancy (especially third trimester)

Interaction

• Anticoagulants (increased bleeding risk)
• Other NSAIDs (additive GI toxicity)
• ACE inhibitors/diuretics (reduced renal function)
• Lithium (risk of toxicity)

Warning and Precautions

• Monitor renal and hepatic function during long-term use
• Use cautiously in elderly patients
• Discontinue if GI bleeding occurs
• Not recommended during pregnancy unless essential

Dosage

As directed by the Physician.