Naproxen + Pheniramine Maleate + Paracetamol + Drotaverine + Caffeine Tablets

Project Image
Thumb Image

Therapeutic Indication

Osteoarthritis
Rheumatoid arthritis
Ankylosing spondylitis
Musculoskeletal pain
Dysmenorrhea (menstrual pain)
Acute gout
Allergic conditions
Headache and migraine
Abdominal cramps
Fatigue-related pain
+91 85919 78885

Naproxen + Pheniramine Maleate + Paracetamol + Drotaverine + Caffeine

Tablet

This combination tablet provides multi‑modal relief by combining the anti‑inflammatory action of Naproxen, antihistamine effect of Pheniramine Maleate, analgesic and antipyretic properties of Paracetamol, antispasmodic action of Drotaverine Hydrochloride, and stimulant effect of Caffeine.

Speciality Orthopedics | Rheumatology | Gynecology | Internal Medicine | Allergy | Neurology
Tags NSAID | Antihistamine | Analgesic | Antispasmodic | Stimulant | Pain Relief | Allergy Control
Strength
  • Naproxen 250 mg
  • Pheniramine Maleate 25 mg
  • Paracetamol 500 mg
  • Drotaverine Hydrochloride 40 mg
  • Caffeine 30 mg
Packing Size
  • 10 Tablets

Check all Men Range

Click to know More

Mechanism

Naproxen inhibits COX enzymes reducing prostaglandins; Pheniramine blocks histamine H1 receptors; Paracetamol acts centrally to reduce pain and fever; Drotaverine relaxes smooth muscles by inhibiting phosphodiesterase; Caffeine stimulates the CNS and enhances analgesic efficacy.

Pharmacokinetics

  • Absorption: Rapid oral absorption for all components.
  • Metabolism: Primarily hepatic metabolism.
  • Excretion: Renal excretion.
  • Half-life: Varies per component (Naproxen ~12–17 hrs, Paracetamol ~2–3 hrs, Drotaverine ~7–9 hrs, Caffeine ~3–5 hrs).

Side Effects

  • Gastrointestinal upset
  • Drowsiness
  • Dizziness
  • Headache
  • Insomnia (due to caffeine)
  • Rare: GI bleeding, renal impairment, liver toxicity

Contraindication

  • Hypersensitivity to any component
  • History of GI bleeding or peptic ulcer
  • Severe renal or hepatic impairment
  • Pregnancy (especially third trimester)
  • Glaucoma or prostatic hypertrophy (due to pheniramine)

Interaction

  • Anticoagulants (increased bleeding risk)
  • Other NSAIDs (additive GI toxicity)
  • Alcohol (enhanced sedation and liver toxicity)
  • MAO inhibitors (enhanced antihistamine effect)
  • ACE inhibitors/diuretics (reduced renal function)
  • Lithium (risk of toxicity)

Warning and Precautions

  • Monitor renal and hepatic function during long-term use
  • Use cautiously in elderly patients
  • Discontinue if GI bleeding occurs
  • Avoid driving due to drowsiness
  • Not recommended during pregnancy unless essential

Dosage

As directed by the Physician.