Naltrexone Tablets

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Therapeutic Indication

Alcohol use disorder – reduces relapse risk
Opioid dependence – prevents euphoric effects
Relapse prevention in detoxified patients
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Naltrexone

Tablet

Naltrexone Tablets are opioid receptor antagonists indicated for the treatment of alcohol dependence and opioid dependence. They reduce cravings, block euphoric effects, and support long-term recovery programs when combined with counseling and psychosocial support.

Speciality Opioid Antagonist
Tags Alcohol Use Disorder | Opioid Dependence | Relapse Prevention | Opioid Antagonist
Strength
  • 1.5 mg
  • 50 mg
Packing Size
  • 10 Tablets

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Mechanism

Naltrexone is a pure opioid antagonist that competitively binds to mu, kappa, and delta opioid receptors. By blocking these receptors, it prevents opioids from exerting their euphoric and reinforcing effects. In alcohol dependence, it modulates dopaminergic pathways in the mesolimbic system, reducing cravings and the rewarding effects of alcohol consumption.

Pharmacokinetics

  • Absorption: Rapidly absorbed after oral administration; peak plasma concentration within 1 hour.
  • Distribution: Widely distributed; plasma protein binding approximately 21%. Crosses the blood-brain barrier.
  • Metabolism: Extensively metabolized in the liver to active metabolite 6-beta-naltrexol.
  • Elimination: Excreted primarily via urine (renal clearance of metabolites).
  • Half-life: Naltrexone ~4 hours; active metabolite 6-beta-naltrexol ~13 hours, contributing to prolonged activity.

Side Effects

  • Drowsiness
  • Nausea, vomiting, abdominal pain
  • Headache, dizziness, anxiety, insomnia
  • Fatigue, muscle/joint pain
  • Hepatotoxicity – monitor liver function

Contraindication

  • Current opioid use or withdrawal
  • Acute hepatitis or liver failure
  • Hypersensitivity to Naltrexone

Interaction

  • Opioid analgesics (effect blocked, risk of withdrawal)
  • May interact with hepatotoxic drugs

Warning and Precautions

  • Contraindicated in patients currently using opioids
  • Do not use in acute hepatitis or liver failure
  • Monitor liver enzymes regularly
  • Ensure opioid-free period before initiation

Dosage

As directed by the Physician.

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.