Minocycline Tablets

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Therapeutic Indication

Acne vulgaris
Respiratory tract infections
Urinary tract infections
Skin and soft tissue infections
Sexually transmitted infections (e.g., chlamydia)
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Minocycline

Tablet

Minocycline is a tetracycline-class antibiotic with broad-spectrum activity against Gram-positive and Gram-negative bacteria. It is widely used in dermatology for acne vulgaris and in infectious diseases for respiratory, urinary, and skin infections.

Speciality Antibiotic | Tetracycline
Tags Acne | Respiratory | UTI | Skin Infections | STI
Strength
  • 50 mg
  • 100 mg
Packing Size
  • 10 Tablets

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Mechanism

Minocycline inhibits bacterial protein synthesis by binding to the 30S ribosomal subunit, preventing amino acid addition to the growing peptide chain. This action halts bacterial growth (bacteriostatic effect).

Pharmacokinetics

  • Absorption: Rapid oral absorption; not significantly affected by food.
  • Distribution: Widely distributed; penetrates skin, respiratory tract, and urinary tract tissues.
  • Metabolism: Partially metabolized in the liver.
  • Elimination: Excreted via urine and feces.
  • Half-life: Approximately 11–22 hours.

Side Effects

  • Nausea
  • Dizziness, vertigo
  • Skin rash, photosensitivity
  • Tooth discoloration (long-term use).

Contraindication

  • Hypersensitivity: To tetracyclines.
  • Pregnancy & Lactation:Contraindicated due to risk of fetal harm and tooth discoloration.
  • Children:Under 8 years (risk of tooth discoloration).
  • Hepatic impairment: Avoid in severe cases.

Interaction

  • Antacids / Iron / Calcium: Reduce absorption of Minocycline.
  • Warfarin: May enhance anticoagulant effect.
  • Oral contraceptives: Reduced efficacy due to altered gut flora.
  • Retinoids: Increased risk of intracranial hypertension.
  • Penicillin: Antagonistic effect when used together.

Warning and Precautions

  • Liver and renal function during prolonged therapy
  • Avoid excessive sun exposure
  • Use cautiously in patients with autoimmune disorder
  • Discontinue if signs of intracranial hypertension occur