Metoclopramide Tablets

Therapeutic Indication

Gastroesophageal reflux disease (GERD)

Diabetic gastroparesis

Short-term nausea and vomiting management

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Sertraline

Tablet

Metoclopramide is a gastrointestinal stimulant and antiemetic. It enhances stomach emptying and reduces reflux symptoms. It is prescribed for GERD and diabetic gastroparesis but should not be used longer than 12 weeks due to risk of tardive dyskinesia.

Speciality	Gastroenterology \| Internal Medicine
Tags	GERD \| Gastroparesis \| Antiemetic
Strength	5 mg 10 mg
Packing Size	10 Tablets

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Mechanism

Metoclopramide blocks dopamine receptors and enhances acetylcholine activity in the GI tract, increasing gastric motility and accelerating stomach emptying.

Pharmacokinetics

Absorption: Rapid oral absorption
Distribution: Crosses blood-brain barrier
Metabolism: Hepatic metabolism
Elimination: Renal excretion
Half-life: ~5–6 hours

Side Effects

Drowsiness
Fatigue
Restlessness
Diarrhea
Tardive dyskinesia (serious risk)

Contraindication

History of tardive dyskinesia
GI obstruction, bleeding, or perforation
Epilepsy or seizure disorders
Pheochromocytoma

Interaction

Antipsychotics (increased risk of movement disorders)
MAO inhibitors
Alcohol and CNS depressants
Digoxin (reduced absorption)
CYP2D6 substrates

Warning and Precautions

Limit use to 12 weeks maximum
Monitor for involuntary movements
Use with caution in elderly and renal impairment
Avoid alcohol during treatment

Dosage

As directed by the Physician.

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Please consult a healthcare professional before using any medicinal product.