Methylcobalamin Tablets

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Therapeutic Indication

Peripheral neuropathy
Diabetic neuropathy
Vitamin B12 deficiency
Megaloblastic anemia
Neurodegenerative disorders (adjunct therapy)
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Methylcobalamin

Tablet

Methylcobalamin is the neurologically active form of Vitamin B12. It plays a vital role in nerve regeneration, red blood cell formation, and DNA synthesis. It is widely used in the management of neuropathies and B12 deficiency-related conditions.

Speciality Neurology | Diabetology | Hematology
Tags Peripheral Neuropathy | Diabetic Neuropathy | Vitamin B12 Deficiency | Neuroprotective
Strength
  • 500 mcg
  • 1500 mcg
Packing Size
  • 10 Tablets

Check all Tablet Range

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Mechanism

Methylcobalamin acts as a coenzyme in the methionine synthase pathway, essential for DNA synthesis and red blood cell formation. It promotes myelin sheath regeneration and enhances nerve conduction, making it effective in neuropathic conditions.

Pharmacokinetics

  • Absorption: Well absorbed orally; enhanced with intrinsic factor.
  • Distribution: Widely distributed; stored in liver.
  • Metabolism: Converted to active coenzyme forms.
  • Elimination: Excreted in urine and bile.
  • Half-life: ~6–7 hours.

Side Effects

  • Mild diarrhea
  • Headache
  • Nausea
  • Rare: hypersensitivity reactions

Contraindication

  • Hypersensitivity to Vitamin B12 or cobalt
  • Leber’s disease (hereditary optic neuropathy)

Interaction

  • Chloramphenicol: May reduce hematologic response.
  • Alcohol: Chronic use may impair absorption.

Warning and Precautions

  • Monitor Vitamin B12 levels during therapy.
  • Use cautiously in patients with renal impairment.
  • Long-term therapy may be required in chronic deficiency.
  • Use cautiously in pregnancy/lactation.

Dosage

As directed by the Physician.