Methoxsalen Tablets

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Therapeutic Indication

Vitiligo
Psoriasis
Certain skin disorders requiring PUVA therapy
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Methoxsalen

Tablet

Methoxsalen is a psoralen derivative used in PUVA (Psoralen + UVA) therapy. It sensitizes the skin to UVA light, promoting repigmentation in vitiligo and reducing excessive cell proliferation in psoriasis.

Speciality Dermatology | Internal Medicine
Tags Psoralen | PUVA Therapy | Vitiligo | Psoriasis
Strength
  • 1 g
Packing Size
  • 10 Tablets

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Mechanism

Methoxsalen intercalates into DNA and, upon UVA exposure, forms cross-links that modify cell proliferation and immune responses, aiding in repigmentation and reducing hyperproliferation.

Pharmacokinetics

  • Absorption: Well absorbed orally.
  • Metabolism: Extensively metabolized in liver.
  • Excretion: Primarily via urine.
  • Half-life: ~2–3 hours.

Side Effects

  • Nausea
  • Itching
  • Redness
  • Photosensitivity
  • Long-term: Increased risk of skin aging and carcinoma

Contraindication

  • Hypersensitivity to psoralens
  • Pregnancy
  • Porphyria
  • History of skin cancer

Interaction

  • Other photosensitizing agents (additive effect)
  • CYP inhibitors (altered metabolism)

Warning and Precautions

  • Strictly avoid sunlight exposure after intake without UVA therapy
  • Monitor for skin changes during long-term use
  • Not recommended during pregnancy unless essential

Dosage

As directed by the Physician.