Methimazole Tablets

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Therapeutic Indication

Hyperthyroidism
Graves’ disease
Preparation for thyroid surgery or radioactive iodine therapy
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Methimazole

Tablet

Methimazole is an antithyroid agent used to treat hyperthyroidism, including Graves’ disease. It works by inhibiting thyroid hormone synthesis, helping restore normal thyroid function.

Speciality Endocrinology | Thyroid Disorders | Internal Medicine
Tags Hyperthyroidism | Graves’ Disease | Antithyroid | Thyroid Hormone Inhibitor
Strength
  • 5 mg
  • 10 mg
Packing Size
  • 15 Tablets

Check all Tablet Range

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Mechanism

Methimazole inhibits thyroid peroxidase enzyme, blocking the iodination of tyrosine residues and coupling reactions in thyroglobulin. This prevents synthesis of thyroid hormones (T3 and T4).

Pharmacokinetics

  • Absorption: Calcium absorbed in the small intestine (requires vitamin D); magnesium absorbed in ileum and colon; zinc absorbed in jejunum.
  • Distribution: Calcium stored in bones and teeth; magnesium distributed in muscle and soft tissues; zinc bound to albumin and widely distributed.
  • Metabolism: Minerals are not metabolized but act as cofactors in enzymatic reactions.
  • Elimination: Calcium excreted via feces and urine; magnesium primarily via urine; zinc via feces and urine.
  • Half-life: Calcium and magnesium levels depend on dietary intake and bone turnover; zinc turnover is relatively rapid with daily requirement replenishment.

Side Effects

  • Skin rash
  • Pruritus
  • Arthralgia
  • Gastrointestinal upset
  • Rare: Agranulocytosis, hepatotoxicity

Contraindication

  • Hypersensitivity to Methimazole
  • Pregnancy (first trimester)
  • Severe hepatic impairment

Interaction

  • May enhance anticoagulant effect of warfarin
  • Interacts with digoxin and theophylline (dose adjustments may be needed)

Warning and Precautions

  • Monitor blood counts regularly (risk of agranulocytosis)
  • Monitor liver function during therapy
  • Advise patients to report sore throat or fever immediately

Dosage

As directed by the Dietician.

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.