Metformin Extended Release Tablets

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Therapeutic Indication

Type 2 Diabetes Mellitus
Improves glycemic control
First-line therapy with diet & exercise
Can be combined with other antidiabetic agents
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Metformin Extended Release

Tablet

Metformin ER is an oral antidiabetic drug that reduces hepatic glucose production, improves insulin sensitivity, and enhances peripheral glucose uptake.

Speciality Endocrinology | Diabetology
Tags Type 2 Diabetes | Glycemic Control
Strength
  • 500 mg
  • 750 mg
  • 1000 mg
Packing Size
  • 10 Tablets

Check all Tablet Range

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Mechanism

Metformin decreases hepatic gluconeogenesis, increases insulin sensitivity, and promotes glucose uptake in muscle and fat tissue.

Pharmacokinetics

  • Absorption: Slower, steady release in ER form.
  • Metabolism: Not significantly metabolized.
  • Excretion: Renal elimination.
  • Half-life: ~6 hours (ER prolongs effect).

Side Effects

  • Gastrointestinal upset (nausea, diarrhea)
  • Metallic taste
  • Rare: Lactic acidosis

Contraindication

  • Severe renal impairment
  • Metabolic acidosis (including diabetic ketoacidosis)

Interaction

  • Iodinated contrast agents (risk of lactic acidosis)
  • Alcohol (increases lactic acidosis risk)
  • Other antidiabetic drugs (risk of hypoglycemia when combined)

Warning and Precautions

  • Monitor renal function regularly
  • Avoid excessive alcohol intake
  • Discontinue before radiologic studies with iodinated contrast
  • Use with caution in elderly patients

Dosage

As directed by the Physician.