Mefenamic Acid + Paracetamol Tablets

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Therapeutic Indication

Pain relief (mild to moderate)
Fever reduction
Dysmenorrhea (menstrual pain)
Musculoskeletal pain
Headache and dental pain
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Mefenamic Acid + Paracetamol

Tablet

This fixed-dose combination provides effective analgesic and antipyretic action. Mefenamic Acid, a non-steroidal anti-inflammatory drug (NSAID), reduces inflammation and pain. Paracetamol provides antipyretic and analgesic effects. Together, they offer enhanced relief in fever, pain, and inflammatory conditions.

Speciality General Medicine | Gynecology | Orthopedics | Dentistry
Tags Antihistamine | AllergyAnalgesic | Antipyretic | NSAID + Paracetamol Relief
Strength
  • Mefenamic Acid 500 mg
  • Paracetamol 325 mg
Packing Size
  • 10 Tablets

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Mechanism

Mefenamic Acid: Inhibits cyclooxygenase (COX) enzymes, reducing prostaglandin synthesis and thereby decreasing inflammation, pain, and fever.
Paracetamol: Acts centrally on the hypothalamus to reduce fever and modulates pain pathways to enhance analgesic effect. The combination provides synergistic relief in pain and fever.

Pharmacokinetics

  • Absorption: Both rapidly absorbed orally.
  • Distribution: Mefenamic Acid protein binding ~90%; Paracetamol widely distributed.
  • Metabolism: Mefenamic Acid hepatic metabolism; Paracetamol via hepatic conjugation.
  • Elimination: Both excreted in urine.
  • Half-life: Mefenamic Acid ~2 hrs; Paracetamol ~2–3 hrs.

Side Effects

  • Gastrointestinal discomfort
  • Nausea
  • Dizziness
  • Headache
  • Rare: Liver toxicity (Paracetamol high dose)
  • Rare: Gastric ulceration (Mefenamic Acid)

    • Contraindication

    • Hypersensitivity to Mefenamic Acid or Paracetamol
    • Severe hepatic impairment
    • Peptic ulcer disease
    • Pregnancy (use with caution)

    Interaction

    • Alcohol (increases risk of liver toxicity with Paracetamol)
    • Other NSAIDs (additive GI risk)
    • Warfarin (Paracetamol may alter INR)

    Warning and Precautions

    • Use under medical supervision only
    • Do not exceed recommended dose (risk of hepatotoxicity)
    • Caution in patients with gastric ulcer history
    • Consult physician during pregnancy and lactation

    Dosage

    As directed by the Physician.

    Disclaimer

    All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
    As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
    Please consult a healthcare professional before using any medicinal product.