Memantine + Donepezil Tablets

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Therapeutic Indication

Alzheimer’s disease (mild to moderate dementia)
Severe Alzheimer’s dementia (symptomatic treatment)
Cognitive decline associated with neurodegenerative disorders
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Memantine + Donepezil

Tablet

This fixed-dose combination is indicated for the treatment of moderate to severe Alzheimer's disease. Memantine acts as an NMDA receptor antagonist, reducing excitotoxicity, while Donepezil is a cholinesterase inhibitor that enhances acetylcholine levels in the brain.

Speciality Neurology | Psychiatry | Geriatric Medicine
Tags Alzheimer’s | Dementia | Cognitive Function | Neuroprotection
Strength
  • Memantine 5 mg
  • Donepezil 5 mg\10 mg
Packing Size
  • 10 Tablets

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Mechanism

Memantine: Blocks NMDA receptors, preventing excess glutamate activity and neuronal damage.
Donepezil: Inhibits acetylcholinesterase, increasing acetylcholine availability and improving cognitive function.

Pharmacokinetics

  • Memantine: Oral absorption, half-life ~60–80 hours, excreted unchanged in urine.
  • Donepezil: Well absorbed, metabolized in liver (CYP450), half-life ~70 hours.

Side Effects

  • Dizziness, headache
  • Nausea, diarrhea
  • Bradycardia (rare)
  • Confusion or hallucinations (possible)

Contraindication

  • Severe renal impairment (for Memantine)
  • Bradyarrhythmias or conduction abnormalities (for Donepezil)
  • Hypersensitivity to either drug

Interaction

  • Other NMDA antagonists (e.g., amantadine)
  • Anticholinergic drugs (reduce Donepezil efficacy)
  • CYP3A4 and CYP2D6 inhibitors (increase Donepezil levels)

Warning and Precautions

  • Use under medical supervision only
  • Monitor cognitive function and behavioral changes
  • Caution in patients with seizure disorders
  • Assess renal and hepatic function before initiation

Dosage

As directed by the Physician.

Dosage

As directed by the Physician.

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.