Lornoxicam +
Thiocolchicoside Tablets

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Therapeutic Indication

Painful muscle spasm
Low back pain & sciatica
Degenerative vertebral disorders
Post-traumatic & post-operative pain
Osteoarthritis & inflammatory joint disorders
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Lornoxicam + Thiocolchicoside

Tablet

A rapid, non-sedative combination of NSAID with Muscle relaxant, having anti- inflammatory and antipyretic actions with least GIT related side-effects to treat painful muscle spasms. Lornoxicam is a non-steroidal anti-inflammatory drug (NSAID) of the oxicam class with analgesic (pain relieving), anti-inflammatory and antipyretic (fever reducing) properties. It is a both COX-1 and COX-2 inhibitor. It is distinguished from established oxicams by a relatively short elimination half-life (3 to 5 hours), which may be advantageous from a tolerability standpoint. The absolute bioavailability of Lornoxicam is 90-100% and no first pass effect was observed. This proven NSAID is combined with a muscle relaxant, Thiocolchicoside with anti-inflammatory, analgesic, and anesthetic actions with minimal side effects. Rapidly onset of action is another unique feature of this drug. Although muscle relaxant have major side effect of Sedation, but Thiocholchicoside is free from sedation effect possible due to non- interference with nicotinic receptors.

Speciality NSAID | Muscle Relaxant
Tags Pain Relief | Muscle Relaxant | Anti-inflammatory
Strength
  • Lornoxicam 4 mg/ 8 mg
  • Thiocolchicoside 4 mg
Packing Size
  • 10 Tablets

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Mechanism

Lornoxicam + Thiocolchicoside works through a dual mechanism by combining anti-inflammatory and muscle relaxant actions for enhanced therapeutic benefit. Lornoxicam inhibits cyclooxygenase enzymes (COX-1 and COX-2), thereby reducing the synthesis of prostaglandins responsible for pain, inflammation, and swelling at the site of injury.
Thiocolchicoside acts centrally on inhibitory neurotransmitter pathways, particularly GABA-A and glycine receptors in the spinal cord, leading to muscle relaxation and reduction of painful muscle spasms without causing significant sedation. The combination provides a synergistic effect where Lornoxicam reduces inflammation and pain, while Thiocolchicoside relieves associated muscle spasm. This results in faster pain relief, improved mobility, and better functional recovery in musculoskeletal conditions such as low back pain, cervical pain, and sciatica.

Pharmacokinetics

  • Absorption: Rapid oral absorption.
  • Distribution: Highly protein bound.
  • Metabolism: Hepatic metabolism.
  • Elimination: Excreted via urine and feces.

Side Effects

  • Nausea and vomiting
  • Stomach pain or indigestion
  • Diarrhea
  • Dizziness
  • Rarely gastrointestinal irritation

Contraindication

  • Peptic ulcer or GI bleeding
  • Severe liver or kidney disease
  • Hypersensitivity to NSAIDs
  • Pregnancy and lactation

Interaction

  • Anticoagulants (increased bleeding risk)
  • Methotrexate (increased toxicity)
  • ACE inhibitors and diuretics
  • Alcohol (increased liver toxicity risk)

Warning and Precautions

  • Use lowest effective dose
  • Monitor liver and kidney function
  • Avoid long-term unsupervised use
  • Use cautiously in elderly patients