Lisinopril Tablets - Hypertension Treatment

Therapeutic Indication

Hypertension (High Blood Pressure)

Heart Failure

Acute Myocardial Infarction

Prevention of cardiovascular events

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Lisinopril

Tablet

Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor used in the management of hypertension and heart failure. It works by relaxing blood vessels, thereby lowering blood pressure and improving blood flow. It is also beneficial in reducing the risk of cardiovascular events following myocardial infarction.

Speciality	Cardiology
Tags	ACE Inhibitor \| Antihypertensive
Strength	2.5 mg 5 mg 10 mg
Packing Size	10 Tablets

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Mechanism

Lisinopril inhibits the angiotensin-converting enzyme (ACE), preventing the conversion of angiotensin I to angiotensin II. This leads to vasodilation, reduced aldosterone secretion, and decreased blood pressure.

Pharmacokinetics

Absorption: Slowly absorbed; bioavailability ~25%.
Distribution: Not significantly protein bound.
Metabolism: Not metabolized; active drug.
Elimination: Excreted unchanged via kidneys.
Half-life: Approximately 12 hours.

Side Effects

Dry cough
Dizziness
Hypotension
Hyperkalemia
Fatigue

Contraindication

History of angioedema
Pregnancy
Hypersensitivity to ACE inhibitors
Severe renal artery stenosis

Interaction

Diuretics: Increased risk of hypotension
Potassium supplements: Risk of hyperkalemia
NSAIDs: Reduced antihypertensive effect
Lithium: Increased lithium toxicity

Warning and Precautions

This has been prescribed for the patient's specific condition. It may be dangerous to any other person.

Monitor blood pressure regularly
Use cautiously in renal impairment
Avoid during pregnancy
Monitor potassium levels
Start with low dose in elderly patients