Liothyronine Tablets

Mechanism

Liothyronine acts as a synthetic T3 hormone, entering cells and binding to nuclear thyroid hormone receptors. This stimulates gene transcription and protein synthesis, increasing metabolic rate, oxygen consumption, and energy utilization.

Pharmacokinetics

• Absorption: Rapidly absorbed orally, bioavailability ~95%.
• Distribution: Widely distributed, binds to plasma proteins.
• Metabolism: Metabolized in the liver and peripheral tissues.
• Elimination: Excreted via urine and bile.
• Half-life: ~2 days.

Side Effects

• Palpitations
• Insomnia
• Weight loss
• Heat intolerance
• Diarrhea
• Arrhythmias (rare)

Contraindication

• Untreated thyrotoxicosis
• Uncorrected adrenal insufficiency
• Recent myocardial infarction
• Pregnancy (use with caution)

Interaction

• Anticoagulants (enhanced effect)
• Antidiabetic drugs (reduced efficacy)
• Digitalis glycosides (altered response)
• Iron and calcium supplements (reduce absorption)

Warning and Precautions

• Use under medical supervision
• Monitor thyroid function regularly
• Adjust dose carefully to avoid hyperthyroidism
• Not recommended in patients with severe cardiac disease

Dosage

As directed by the Physician.