Linagliptin + Metformin Tablets

Project Image
Thumb Image

Therapeutic Indication

Type 2 Diabetes Mellitus
Improves glycemic control as adjunct to diet and exercise
+91 85919 78885

Linagliptin + Metformin

Tablet

Linagliptin is a DPP-4 inhibitor that increases incretin levels, enhancing insulin secretion and reducing glucagon release. Metformin is a biguanide that decreases hepatic glucose production and improves insulin sensitivity. Together, they provide effective glycemic control in Type 2 Diabetes Mellitus.

Speciality Endocrinology | Internal Medicine
Tags DPP-4 Inhibitor | Biguanide | Diabetes Management
Strength
  • Linagliptin 2.5 mg + Metformin 500 mg
  • Linagliptin 2.5 mg + Metformin 800 mg
Packing Size
  • 10 Tablets

Check all Tablets Range

Click to know More

Mechanism

Linagliptin inhibits DPP-4, prolonging incretin activity and enhancing insulin secretion. Metformin reduces hepatic glucose output and improves peripheral glucose uptake.

Pharmacokinetics

  • Absorption: Linagliptin rapidly absorbed; Metformin bioavailability ~50–60%.
  • Metabolism: Linagliptin minimally metabolized; Metformin not metabolized.
  • Excretion: Linagliptin via bile/feces; Metformin via urine.
  • Half-life: Linagliptin ~12 hours; Metformin ~6 hours.

Side Effects

  • Hypoglycemia (rare, usually with sulfonylureas)
  • Gastrointestinal upset (nausea, diarrhea)
  • Headache
  • Nasopharyngitis
  • Rare: Lactic acidosis (Metformin)

Contraindication

  • Severe renal impairment
  • Metabolic acidosis
  • Hypersensitivity to Linagliptin or Metformin

Interaction

  • Alcohol (increases risk of lactic acidosis)
  • Other antidiabetic drugs (risk of hypoglycemia)
  • Strong CYP3A4/5 inhibitors (affect Linagliptin levels)

Warning and Precautions

  • Monitor renal function regularly
  • Use cautiously in elderly patients
  • Discontinue if lactic acidosis suspected
  • Not recommended during pregnancy unless essential

Dosage

As directed by the Physician.

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.