Levetiracetam Tablets

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Therapeutic Indication

Partial-onset seizures (monotherapy or adjunct)
Myoclonic seizures in juvenile myoclonic epilepsy
Primary generalized tonic-clonic seizures
Adjunct therapy in refractory epilepsy
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Levetiracetam

Tablet

Levetiracetam is a broad-spectrum antiepileptic drug. It is effective in controlling partial-onset, myoclonic, and generalized tonic-clonic seizures. Its unique mechanism of action and favorable safety profile make it a preferred choice in epilepsy management.

Speciality Neurology | Epilepsy Management
Tags Antiepileptic | Seizure Control | Epilepsy | Myoclonic Seizures
Strength
  • 250 mg
  • 500 mg
  • 750 mg
  • 1000 mg
Packing Size
  • 10 Tablets

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Mechanism

Levetiracetam binds to synaptic vesicle protein SV2A, modulating neurotransmitter release and reducing neuronal excitability. This unique mechanism distinguishes it from other antiepileptic drugs and contributes to its broad-spectrum efficacy.

Pharmacokinetics

  • Absorption: Rapid oral absorption; bioavailability ~100%.
  • Distribution: Minimal protein binding (<10%).
  • Metabolism: Limited hepatic metabolism.
  • Elimination: Primarily excreted unchanged in urine.
  • Half-life: ~6–8 hours (extended in renal impairment).

Side Effects

  • Somnolence, dizziness
  • Headache
  • Irritability, mood changes
  • Rare: suicidal ideation, Stevens-Johnson syndrome

Contraindication

  • Hypersensitivity to Levetiracetam
  • Severe renal impairment (dose adjustment required)

Interaction

  • Minimal drug interactions compared to other antiepileptics.
  • Caution with CNS depressants (additive sedation).

Warning and Precautions

  • Monitor psychiatric symptoms (depression, aggression).
  • Adjust dose in renal impairment.
  • Gradual withdrawal recommended to avoid seizure rebound.

Dosage

As directed by the Physician.