L-Arginine + Calcium + Calcitriol + Vitamin D3 Tablets

Mechanism

L-Arginine: Improves blood flow by boosting nitric oxide.
Calcium: Essential for bone mineralization and muscle contraction.
Calcitriol: Regulates calcium and phosphate metabolism.
Vitamin D3: Enhances calcium absorption and maintains bone density.

Pharmacokinetics

• Absorption: Calcium and Vitamin D3 absorbed in the intestine; L-Arginine absorbed systemically.
• Distribution: Calcium stored in bones; Vitamin D3 in fat and muscle; L-Arginine circulates in plasma.
• Metabolism: Calcitriol metabolized in liver/kidneys; L-Arginine partly metabolized in liver.
• Elimination: Calcium excreted via urine/feces; Vitamin D3 via bile; L-Arginine via urine.
• Half-life: Vitamin D3 ~15 days; L-Arginine ~1–2 hrs.

Side Effects

• Gastrointestinal discomfort
• Nausea
• Constipation (Calcium)
• Hypercalcemia (Vitamin D3 overdose)
• Rare: Allergic reactions

Contraindication

• Hypersensitivity to any component
• Severe renal impairment
• Hypercalcemia or hypervitaminosis D
• Pregnancy and lactation (use with medical advice)

Interaction

• Calcium supplements (risk of hypercalcemia)
• Glucocorticoids (reduce Vitamin D3 efficacy)
• Anticonvulsants (increase Vitamin D3 metabolism)
• Other vasodilators (additive effect with L-Arginine)

Warning and Precautions

• Use under medical supervision only
• Monitor calcium and Vitamin D levels during therapy
• Discontinue if hypercalcemia symptoms occur
• Advise patients to avoid excessive Vitamin D supplementation