Ivabradine Tablets | DM Pharma India

Therapeutic Indication

Chronic stable angina pectoris

Heart failure with reduced ejection fraction (HFrEF)

Reduction of heart rate in sinus rhythm patients

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Ivabradine

Tablet

Ivabradine is a selective sinus node inhibitor used in cardiology. It reduces heart rate without affecting myocardial contractility or intracardiac conduction. It is indicated for angina and heart failure patients who remain symptomatic despite optimal therapy.

Speciality	Cardiology \| Internal Medicine
Tags	Anti-anginal \| Heart Failure \| Cardiology
Strength	5 mg 7.5 mg
Packing Size	10 Tablets

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Mechanism

Ivabradine selectively inhibits the If (funny) current in the sinoatrial node. This slows diastolic depolarization, reduces heart rate, and decreases myocardial oxygen demand. It does not affect contractility or blood pressure.

Pharmacokinetics

Absorption: Rapid oral absorption; bioavailability ~40%.
Distribution: Widely distributed; protein binding ~70%.
Metabolism: Hepatic metabolism via CYP3A4.
Elimination: Excreted in urine and feces.
Half-life: ~2 hours (active metabolite ~11 hours).

Side Effects

Bradycardia
Visual disturbances (phosphenes)
Dizziness
Headache
Hypertension

Contraindication

Hypersensitivity to Ivabradine
Acute heart failure
Severe bradycardia or conduction disorders
Concomitant use with strong CYP3A4 inhibitors
Pregnancy and lactation

Interaction

Ketoconazole, clarithromycin (increase Ivabradine levels)
Other bradycardic agents (beta-blockers, digoxin)
Grapefruit juice (increases plasma concentration)

Warning and Precautions

Use under medical supervision only
Monitor heart rate regularly
Caution in patients with atrial fibrillation
Consult physician during pregnancy and lactation

Dosage

As directed by the Physician.