Isoxsuprine Tablets 10 mg

Therapeutic Indication

Premature labor (uterine relaxant)

Peripheral vascular diseases (Buerger’s disease, arteriosclerosis obliterans, Raynaud’s phenomenon)

Cerebrovascular insufficiency

Improvement of blood circulation in ischemic conditions

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Isoxsuprine

Tablet

Isoxsuprine is a vasodilator and smooth muscle relaxant. It dilates blood vessels, improving circulation in peripheral and cerebral vascular disorders, and relaxes uterine smooth muscle to delay premature labor. Its dual action makes it useful in both obstetrics and vascular medicine.

Speciality	Vasodilator \| Uterine Relaxant
Tags	Premature Labor \| Vasodilator \| Peripheral Vascular Disease \| Cerebrovascular Insufficiency
Strength	40 mg
Packing Size	10 Tablets

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Mechanism

Isoxsuprine acts directly on vascular smooth muscle, causing vasodilation and improved blood flow. It also relaxes uterine smooth muscle, reducing contractions and delaying premature labor.

Pharmacokinetics

Absorption: Rapid oral absorption
Distribution: Acts primarily on vascular smooth muscle
Metabolism: Hepatic metabolism
Elimination: Excreted via urine and feces
Half-life: Short, requiring multiple daily doses

Side Effects

Dizziness
Nausea
Headache
Flushing
Abdominal discomfort
Rare: tachycardia, hypotension, chest pain

Contraindication

Immediate postpartum period (risk of bleeding)
Active arterial bleeding
Cardiac disease (ischemic heart disease, arrhythmias)
Bleeding disorders
Glaucoma
Not FDA-approved for prevention of preterm labor

Interaction

Beta-adrenergic agonists — additive cardiovascular effects
Antihypertensives — enhanced hypotensive effect
CNS depressants — increased dizziness or drowsiness
Alcohol — worsens dizziness and reduces efficacy
Other vasodilators — additive vasodilation, risk of hypotension

Warning and Precautions

Monitor liver function during therapy
Use as adjunct therapy, not replacement for medical treatment
Consult physician before long-term use