Imipramine Tablets

Therapeutic Indication

Major depressive disorder

Anxiety and panic disorders

Nocturnal enuresis (bedwetting in children)

Neuropathic pain (off-label)

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Imipramine

Tablet

Imipramine is a tricyclic antidepressant (TCA) used to treat depression, anxiety disorders, and nocturnal enuresis. It works by inhibiting the reuptake of serotonin and norepinephrine, enhancing mood and emotional stability.

Speciality	Psychiatry \| Neurology \| Pediatrics
Tags	Depression \| Anxiety \| Enuresis \| Neuropathic Pain
Strength	25 mg 50 mg
Packing Size	10 Tablets

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Mechanism

Imipramine inhibits the reuptake of serotonin and norepinephrine at presynaptic terminals, increasing their availability in the synaptic cleft. This enhances neurotransmission and improves mood. It also has anticholinergic and antihistaminic properties, contributing to its sedative and side-effect profile.

Pharmacokinetics

Absorption: Well absorbed orally
Distribution: Highly protein bound (~95%)
Metabolism: Extensively metabolized in the liver to active metabolite desipramine
Half-life: ~8–20 hours
Excretion: Metabolites excreted in urine

Side Effects

Nausea
Drowsiness
Dry mouth
Constipation
Weight gain
Orthostatic hypotension
Cardiac arrhythmias (rare)

Contraindication

Recent myocardial infarction
Cardiac conduction abnormalities
Hypersensitivity to Imipramine or TCAs

Interaction

MAO inhibitors: risk of hypertensive crisis
SSRIs: ↑ risk of serotonin syndrome
Alcohol/CNS depressants: additive sedation
Antiarrhythmics: ↑ risk of cardiac conduction abnormalities

Warning and Precautions

Monitor cardiac function in elderly patients
Use caution in patients with seizure disorders
Risk of suicidal ideation in young adults
Gradual dose adjustment recommended

Dosage

As directed by the Physician.