Imipramine + Diazepam Tablets

Therapeutic Indication

Depression with anxiety

Panic disorders

Psychosomatic disorders

Insomnia associated with anxiety

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Imipramine + Diazepam

Tablet

Imipramine is a tricyclic antidepressant that enhances serotonin and norepinephrine activity, while Diazepam is a benzodiazepine that provides anxiolytic, sedative, and muscle relaxant effects. Together, they are used in managing depression with anxiety and related conditions.

Speciality	Psychiatry \| Internal Medicine \| Neurology
Tags	Antidepressant \| Anxiolytic \| Benzodiazepine \| Tricyclic
Strength	Imipramine 25 mg + Diazepam 2 mg Imipramine 25 mg + Diazepam 5 mg
Packing Size	10 Tablets

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Mechanism

Imipramine inhibits reuptake of serotonin and norepinephrine, improving mood and reducing depressive symptoms. Diazepam enhances GABA activity in the brain, producing calming, anxiolytic, and sedative effects.

Pharmacokinetics

Absorption: Both drugs well absorbed orally.
Metabolism: Imipramine extensively metabolized in liver; Diazepam metabolized hepatically to active metabolites.
Excretion: Primarily via urine.
Half-life: Imipramine ~11–25 hours; Diazepam ~20–50 hours.

Side Effects

Drowsiness, dizziness
Dry mouth, constipation
Weight gain
Rare: dependence, withdrawal symptoms

Contraindication

Hypersensitivity to tricyclics or benzodiazepines
Severe hepatic impairment
History of substance abuse
Glaucoma

Interaction

Alcohol (enhanced sedation)
MAO inhibitors (risk of serotonin syndrome)
Other CNS depressants (additive effects)

Warning and Precautions

Risk of dependence with Diazepam
Use with caution in elderly patients
Monitor for suicidal ideation in depression
Not recommended during pregnancy unless essential

Dosage

As directed by the Physician.

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