Therapeutic Indication
| Dermatophytosis (ringworm infections) |
| Onychomycosis (nail infections) |
| Tinea capitis (scalp infection) |
| Tinea corporis (body ringworm) |
| Tinea cruris (jock itch) |
| Tinea pedis (athlete’s foot) |
Griseofulvin
Tablet
Griseofulvin is an antifungal antibiotic derived from Penicillium species. It is primarily used to treat superficial fungal infections of the skin, hair, and nails caused by dermatophytes, including tinea corporis (ringworm of the body), tinea capitis (scalp ringworm), and tinea unguium (onychomycosis or nail infections).
| Speciality | Dermatology | Antifungal |
|---|---|
| Tags | Antifungal | Dermatophytosis | Ringworm | Onychomycosis |
| Strength | 500 mg |
| Packing | 10 Tablets |
Mechanism
Griseofulvin interferes with fungal cell mitosis by binding to microtubular proteins, disrupting spindle formation. It also binds to keratin in human cells, making them resistant to fungal invasion.
Pharmacokinetics
- Absorption: Enhanced with fatty meals.
- Distribution: Deposited in keratin precursor cells (skin, hair, nails).
- Metabolism: Hepatic metabolism.
- Elimination: Excreted in urine and feces.
- Half-life: ~24 hours.
Side Effects
- Headache
- Nausea, vomiting
- Diarrhea
- Fatigue
- Photosensitivity
- Rare: hepatotoxicity, proteinuria
Contraindication
- Hypersensitivity to Griseofulvin
- Severe liver disease
- Porphyria
- Pregnancy (teratogenic risk)
Interaction
- Warfarin: Reduced anticoagulant effect.
- Oral contraceptives: Reduced efficacy.
- Alcohol: May cause disulfiram-like reaction.
- Barbiturates: May reduce Griseofulvin levels.
Warning & Precautions
- Administer with fatty meals to improve absorption.
- Monitor liver function during prolonged therapy.
- Advise patients to avoid alcohol.
- Use effective contraception during and after therapy.
Dosage
As directed by the Physician.