Glucosamine +
Diacerein Tablets

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Therapeutic Indication

Osteoarthritis management
Joint pain and stiffness relief
Cartilage repair and maintenance
Improved mobility and flexibility
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Glucosamine + Diacerein

Tablet

Diacerein is an anthraquinone derivative with anti-inflammatory properties that inhibits interleukin-1 activity, reducing cartilage degradation. Glucosamine is a naturally occurring compound that supports cartilage synthesis and elasticity. Together, they provide synergistic benefits in osteoarthritis management by reducing pain, slowing disease progression, and improving joint function.

Speciality Osteoarthritis Management / Joint Health Supplement
Tags Joint Health | Osteoarthritis | Cartilage Support
Strength
  • Glucosamine 500 mg
  • Diacerein 50 mg
Packing Size
  • 10 Tablets

Check all Tablet Range

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Mechanism

Diacerein inhibits interleukin-1 mediated cartilage degradation and reduces inflammation. Glucosamine supports synthesis of glycosaminoglycans and proteoglycans, essential for cartilage structure and elasticity. The combination helps relieve symptoms and slow progression of osteoarthritis.

Pharmacokinetics

  • Diacerein Absorption: Well absorbed orally, metabolized to rhein
  • Glucosamine Absorption: Rapid oral absorption, concentrated in joint tissues
  • Distribution: Both widely distributed in synovial fluid and cartilage
  • Metabolism: Diacerein hepatic metabolism; Glucosamine minimal hepatic metabolism
  • Elimination: Diacerein via renal and fecal routes; Glucosamine primarily renal
  • Half-life: Diacerein ≈ 4–6 hours; Glucosamine ≈ 2–3 hours

Side Effects

  • Diarrhea (common with Diacerein)
  • Abdominal discomfort
  • Nausea
  • Skin rash (rare)

Contraindication

  • Hypersensitivity to Diacerein or Glucosamine
  • Severe hepatic or renal impairment
  • Shellfish allergy (Glucosamine source)

Interaction

  • Diacerein: May interact with laxatives (enhanced GI effects)
  • Glucosamine: May increase bleeding risk with warfarin and other anticoagulants
  • Use cautiously with hepatotoxic drugs (monitor liver function)
  • Consult healthcare provider before combining with other joint supplements

Warning and Precautions

  • Monitor liver function during therapy
  • Use cautiously in elderly patients
  • Adjust dose in case of persistent diarrhea