Glipizide + Metformin Tablets

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Therapeutic Indication

Type 2 Diabetes Mellitus
Improved glycemic control when diet and exercise are insufficient
Dual mechanism therapy (insulin secretion + insulin sensitivity)
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Glipizide + Metformin

Tablet

This fixed-dose combination provides dual benefits in type 2 diabetes management. Glipizide stimulates insulin secretion, while Metformin reduces hepatic glucose production and improves insulin sensitivity.

Speciality Endocrinology | Diabetology | General Medicine
Tags Sulfonylurea | Biguanide | Type 2 Diabetes | Blood Sugar Control
Strength
  • Glipizide 5 mg
  • Metformin 500 mg
Packing Size
  • 10 Tablets

Check all Tablet Range

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Mechanism

Glipizide binds to sulfonylurea receptors on pancreatic beta cells, closing ATP-sensitive potassium channels and triggering insulin release. Metformin decreases hepatic gluconeogenesis, enhances peripheral glucose uptake, and improves insulin sensitivity.

Pharmacokinetics

  • Glipizide: Rapid absorption, peak plasma concentration in 1–3 hours, metabolized in liver, half-life ~2–4 hours.
  • Metformin: Absorbed in small intestine, bioavailability ~50–60%, excreted unchanged in urine, half-life ~6 hours.

Side Effects

  • Hypoglycemia (due to Glipizide)
  • Gastrointestinal upset (due to Metformin)
  • Lactic acidosis (rare, serious)
  • Weight gain (possible)

Contraindication

  • Hypoglycemia (due to Glipizide)
  • Gastrointestinal upset (due to Metformin)
  • Lactic acidosis (rare, serious)
  • Weight gain (possible)

Interaction

  • Alcohol (increased risk of hypoglycemia and lactic acidosis)
  • Other antidiabetic drugs (additive effect)
  • CYP2C9 inhibitors (may increase Glipizide levels)
  • Nephrotoxic drugs (increase risk with Metformin)

Warning and Precautions

  • Use under medical supervision only
  • Monitor blood glucose regularly
  • Assess renal function before starting Metformin
  • Caution in elderly patients prone to hypoglycemia

Dosage

As directed by the Physician.

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.