Glibenclamide Tablets

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Therapeutic Indication

Type 2 Diabetes Mellitus
Improves glycemic control
Combination therapy for insulin resistance and beta-cell dysfunction
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Glibenclamide

Tablet

Glibenclamide is a sulfonylurea antidiabetic drug indicated for the treatment of type 2 diabetes mellitus. It lowers blood glucose by stimulating insulin secretion from pancreatic beta cells.

Speciality Endocrinology | Diabetology | General Medicine
Tags Sulfonylurea | Type 2 Diabetes | Blood Sugar Control
Strength
  • 2.5 mg
  • 5 mg
Packing Size
  • 10 Tablets

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Mechanism

Glibenclamide binds to sulfonylurea receptors on pancreatic beta cells, closing ATP-sensitive potassium channels. This depolarizes the cell membrane, opens calcium channels, and triggers insulin release.

Pharmacokinetics

  • Absorption: Rapidly absorbed after oral administration.
  • Peak Plasma Concentration: 2–4 hours.
  • Protein Binding: Highly bound (~99%) to plasma proteins.
  • Metabolism: Extensively metabolized in the liver.
  • Excretion: Metabolites excreted via urine and bile.
  • Half-life: ~10 hours (longer in elderly or renal impairment).

Side Effects

  • Hypoglycemia (most significant risk)
  • Weight gain
  • Gastrointestinal upset (nausea, vomiting)
  • Rare: Allergic skin reactions, liver enzyme changes

Contraindication

  • Type 1 Diabetes Mellitus
  • Diabetic ketoacidosis
  • Severe renal or hepatic impairment
  • Hypersensitivity to sulfonylureas

Interaction

  • Alcohol (increases risk of hypoglycemia)
  • Other antidiabetic drugs (additive effect)
  • Beta-blockers (may mask hypoglycemia symptoms)
  • CYP2C9 inhibitors (increase drug levels)

Warning and Precautions

    • Use under medical supervision only
    • Monitor blood glucose regularly
    • Adjust dose in elderly or renal/hepatic impairment
    • Avoid skipping meals to reduce hypoglycemia risk

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.