Gemifloxacin Tablets

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Therapeutic Indication

Community-acquired pneumonia
Acute bacterial exacerbation of chronic bronchitis
Respiratory tract infections
Skin and soft tissue infections
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Gemifloxacin

Tablet

Gemifloxacin is a fluoroquinolone antibiotic used to treat bacterial infections, particularly respiratory tract infections. It works by inhibiting bacterial DNA gyrase and topoisomerase IV, enzymes essential for DNA replication and repair.

Speciality Infectious Diseases | Pulmonology
Tags Antibiotic | Fluoroquinolone | Respiratory | Pneumonia
Strength
  • 320 mg
Packing Size
  • 10 Tablets

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Mechanism

Gemifloxacin inhibits bacterial DNA gyrase and topoisomerase IV, preventing DNA replication and transcription. This results in bacterial cell death and effective infection control.

Pharmacokinetics

  • Absorption: Rapidly absorbed orally.
  • Distribution: Widely distributed in tissues.
  • Metabolism: Limited hepatic metabolism.
  • Elimination: Excreted via urine and feces.
  • Half-life: ~7–8 hours.

Side Effects

  • Nausea, diarrhea
  • Dizziness, headache
  • Skin rash (notably higher incidence)
  • QT prolongation (cardiac risk)
  • Tendonitis or tendon rupture (rare)

Contraindication

  • Hypersensitivity to fluoroquinolones
  • Pregnancy and lactation
  • Children (not recommended)
  • Cardiac arrhythmias

Interaction

  • Antacids, iron, zinc (reduce absorption)
  • Antiarrhythmic drugs (QT prolongation)
  • NSAIDs (risk of seizures)
  • Warfarin (increased anticoagulant effect)

Warning and Precautions

  • Use under medical supervision
  • Monitor ECG in cardiac patients
  • Discontinue if rash develops
  • Avoid excessive sun exposure
  • Adjust dose in renal impairment

Dosage

As directed by the Physician.

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.