Fluoxetine Tablets

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Therapeutic Indication

Major Depressive Disorder
Obsessive-Compulsive Disorder (OCD)
Bulimia Nervosa
Panic Disorder
Premenstrual Dysphoric Disorder (PMDD)
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Fluoxetine

Tablet

Fluoxetine is a selective serotonin reuptake inhibitor (SSRI) used to treat depression, OCD, bulimia nervosa, panic disorder, and PMDD. It works by increasing serotonin levels in the brain to improve mood and emotional stability.

Speciality Psychiatry | Neurology
Tags Depression | OCD | Bulimia | Panic Disorder | PMDD
Strength
  • 20 mg
Packing Size
  • 10 Tablets

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Mechanism

Fluoxetine blocks serotonin reuptake, increasing serotonin availability in the brain to improve mood and reduce anxiety.

Pharmacokinetics

  • Absorption: Well absorbed orally.
  • Metabolism: Liver metabolism via CYP2D6.
  • Excretion: Via urine.
  • Half-life: ~4–6 days (active metabolite ~16 days).

Side Effects

  • Nausea
  • Insomnia
  • Loss of appetite
  • Dry mouth
  • Headache

Contraindication

  • Hypersensitivity to Fluoxetine
  • Concurrent use with MAOIs

Interaction

  • MAOIs (risk of serotonin syndrome)
  • Other SSRIs/SNRIs (additive serotonergic effects)
  • Tricyclic antidepressants (increased plasma levels)
  • Antipsychotics (may alter metabolism)
  • Warfarin (increased bleeding risk)
  • Alcohol (enhanced sedation)

Warning and Precautions

  • Monitor for suicidal thoughts in young adults.
  • Do not stop abruptly; taper under medical supervision.
  • Use caution with other serotonergic drugs (risk of serotonin syndrome).