Fluoxetine–Olanzapine Tablets | Combination Therapy for Depression & Bipolar Disorder

Therapeutic Indication

Bipolar Depression (acute episodes)

Treatment-resistant Major Depressive Disorder

Olanzapine

Tablet

Fluoxetine–Olanzapine tablets combine an SSRI antidepressant (Fluoxetine) and an atypical antipsychotic (Olanzapine) to treat bipolar depression and major depressive disorder resistant to other treatments.

Speciality	Psychiatry \| Neurology
Tags	Depression \| Bipolar Disorder \| Combination Therapy
Strength	Olanzapine 5 mg Fluoxetine 20 mg
Packing Size	10 Tablets

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Mechanism

Fluoxetine increases serotonin levels by inhibiting reuptake, while Olanzapine modulates dopamine and serotonin receptors to stabilize mood and reduce psychotic symptoms.

Pharmacokinetics

Absorption: Well absorbed orally.
Metabolism: Liver metabolism via CYP1A2 and CYP2D6.
Excretion: Via urine and feces.
Half-life: Fluoxetine ~4 days; Olanzapine ~30 hours.

Side Effects

Drowsiness
Weight gain
Dry mouth
Increased appetite
Metabolic changes (glucose, cholesterol)

Contraindication

Hypersensitivity to Fluoxetine or Olanzapine
Concurrent use with MAOIs

Interaction

CYP1A2 inhibitors (fluvoxamine)
CYP2D6 inhibitors (paroxetine)
Alcohol (enhanced sedation)

Warning and Precautions

Monitor weight, glucose, and lipid profile regularly.
Risk of suicidal thoughts in young adults.
Not recommended for elderly patients with dementia-related psychosis.

Fluoxetine + Olanzapine Tablets