Flunarizine Tablets

Mechanism

• Blocks calcium entry into cells, reducing vascular smooth muscle contraction.
• Improves cerebral blood flow and prevents migraine attacks.
• Exerts antihistaminic and sedative effects.

Pharmacokinetics

• Absorption: Well absorbed orally.
• Distribution: Widely distributed, high protein binding.
• Metabolism: Extensively metabolized in liver.
• Excretion: Via urine and feces.

Side Effects

• Drowsiness, fatigue
• Weight gain
• Depression (rare)
• Extrapyramidal symptoms (long-term use)

Contraindication

• Hypersensitivity to Flunarizine
• Depression or history of psychiatric illness
• Parkinson’s disease

Interaction

• May enhance sedative effects of CNS depressants.
• Use cautiously with antiepileptics.
• Alcohol increases drowsiness.

Warning and Precautions

• Monitor patients for depression during therapy.
• Use with caution in elderly patients.
• Not recommended during pregnancy and lactation unless prescribed.

Dosage

As directed by the Physician.