Famciclovir Tablets

Therapeutic Indication

Herpes zoster (shingles)

Genital herpes (initial and recurrent episodes)

Herpes labialis (cold sores)

Suppressive therapy for recurrent genital herpes

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Famciclovir

Tablet

TFamciclovir is an oral antiviral prodrug of penciclovir. It is effective against herpes viruses, reducing viral replication and shortening the duration of symptoms in herpes zoster, genital herpes, and cold sores.

Speciality	Infectious Diseases \| Dermatology \| Gynecology
Tags	Antiviral \| Herpes Zoster \| Genital Herpes \| Cold Sores
Strength	250 mg 500 mg
Packing Size	10 Tablets

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Mechanism

Famciclovir is converted to penciclovir in the body. Penciclovir inhibits viral DNA polymerase, blocking viral DNA synthesis and replication. This reduces viral load and accelerates healing of lesions.

Pharmacokinetics

Absorption: Rapid oral absorption; bioavailability ~77%.
Distribution: Widely distributed in tissues.
Metabolism: Converted to active penciclovir via hepatic metabolism.
Elimination: Excreted primarily in urine.
Half-life: ~2–3 hours (penciclovir intracellular half-life longer).

Side Effects

Headache
Nausea
Diarrhea
Dizziness
Fatigue

Contraindication

Hypersensitivity to Famciclovir or Penciclovir
Severe renal impairment (dose adjustment required)

Interaction

Probenecid: May increase penciclovir plasma levels.
Other nephrotoxic drugs: Increased risk of renal toxicity.

Warning and Precautions

Adjust dose in patients with renal impairment.
Use cautiously in elderly patients.
Not a cure for herpes — reduces symptoms and recurrence.
Advise patients to avoid sexual contact during active lesions.

Dosage

As directed by the Physician.