Dydrogesterone Tablets

Therapeutic Indication

Menstrual disorders (amenorrhea, dysmenorrhea, irregular cycles)

Infertility due to luteal insufficiency

Threatened and recurrent miscarriage

Endometriosis

Hormone replacement therapy (HRT) with estrogens

Premenstrual syndrome (PMS)

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Dydrogesterone

Tablet

Dydrogesterone is a synthetic progestogen structurally related to natural progesterone. It is used to restore normal progesterone levels in gynecological conditions, support pregnancy, and balance estrogen therapy in HRT.

Speciality	Gynecology \| Endocrinology \| Hormone Therapy
Tags	Menstrual Disorders \| Infertility \| Miscarriage Prevention \| HRT \| Endometriosis
Strength	10 mg 20 mg
Packing Size	10 Tablets

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Mechanism

Dydrogesterone binds to progesterone receptors, stabilizing the endometrium, supporting implantation, and maintaining pregnancy. It counteracts estrogen’s proliferative effects on the endometrium, preventing hyperplasia and promoting secretory transformation.

Pharmacokinetics

Absorption: Rapid oral absorption.
Distribution: Widely distributed; plasma protein binding ~90%.
Metabolism: Hepatic metabolism to active metabolites.
Elimination: Excreted in urine as metabolites.
Half-life: ~5–7 hours.

Side Effects

Headache
Nausea
Breast tenderness
Fatigue
Menstrual irregularities
Rare: hypersensitivity reactions

Contraindication

Hypersensitivity to Dydrogesterone
Undiagnosed vaginal bleeding
Known or suspected hormone-dependent tumors
Severe hepatic impairment

Interaction

CYP3A4 inducers: Rifampicin, carbamazepine may reduce efficacy.
Other hormonal therapies: Possible additive effects.

Warning and Precautions

Monitor liver function during therapy.
Use cautiously in patients with cardiovascular risk factors.
Discontinue if jaundice or significant liver dysfunction occurs.
Not recommended in breastfeeding women.

Dosage

As directed by the Physician.