Duloxetine Tablets

Duloxetine

Tablet

Depression is associated with low levels of certain brain chemicals. These chemicals, which are collectively called neurotransmitters, carry messages between brain cells. Certain neurotransmitters—including serotonin and norepinephrine—are known to affect mood. Serotonin is sometimes called a "feel good" chemical because it is associated with positive feelings of wellbeing. Norepinephrine is related to alertness and energy.
Duloxetine is a selective serotonin (5-HT) and norepinephrine (NA) reuptake inhibitor antidepressant (SSNRI). Duloxetine affects chemicals in the brain that may become unbalanced and cause depression. The drug can help improve your mood, sleep, appetite, energy level and decrease nervousness. Duloxetine is prescribed to treat major depressive disorder and general anxiety disorder. It is also used to treat fibromyalgia (a chronic pain disorder), or chronic muscle or joint pain (such as low back pain and osteoarthritis pain). Duloxetine is also used to treat pain caused by nerve damage in people with diabetes (diabetic neuropathy). This pain relieving effects of this drug may be linked to the blockage of sodium ion channels.
Duloxetine is a selective serotonin (5-HT) and norepinephrine (NA) reuptake inhibitor antidepressant (SSNRI). Duloxetine affects chemicals in the brain that may become unbalanced and cause depression. The drug can help improve your mood, sleep, appetite, energy level and decrease nervousness. Duloxetine is prescribed to treat major depressive disorder and general anxiety disorder. It is also used to treat fibromyalgia (a chronic pain disorder), or chronic muscle or joint pain (such as low back pain and osteoarthritis pain). Duloxetine is also used to treat pain caused by nerve damage in people with diabetes (diabetic neuropathy).
It acts on serotonin transporters (SERTs) and norepinephrine transporters (NETs), which are glycoproteins present in synapses. Their function is to take extra neurotransmitters from these synapses and transfer them back to pre-synaptic nerves for further use.
By inhibiting the activity of these transporters, it increases the quantities of both neurotransmitters in the neurons. The increased concentration changes mood and enhances the alertness of a person relieving the symptoms of depression. These chemical messengers are responsible for regulating mental and physical processes other than a person's emotional state.
It has also been found to indirectly increase dopamine in the prefrontal cortex. It is also thought that the pain relieving effects of this drug may be linked to the blockage of sodium ion channels.