Drotaverine Tablets

Mechanism

Drotaverine inhibits phosphodiesterase IV enzyme, increasing cAMP levels in smooth muscle cells. This leads to relaxation of smooth muscles, reduction of spasms, and relief of pain.

Pharmacokinetics

• Absorption: Rapidly absorbed after oral administration; peak plasma concentration in ~2 hours.
• Bioavailability: ~65%.
• Distribution: Widely distributed; plasma protein binding ~95%.
• Metabolism: Extensively metabolized in the liver.
• Excretion: Metabolites excreted via urine and bile.
• Half-life: ~8–10 hours.

Side Effects

• Dizziness
• Nausea
• Hypotension (rare)
• Allergic reactions (rare)

Contraindication

• Hypersensitivity to Drotaverine
• Severe hepatic or renal impairment
• Cardiac conduction disorders

Interaction

• Levodopa (may reduce antiparkinsonian effect)
• Other antispasmodics (additive effect)

Warning and Precautions

• Use under medical supervision only
• Caution in patients with hypotension
• Not recommended in children below 12 years

Dosage

As directed by the Physician.