Doxofylline Tablets

Therapeutic Indication

Asthma management

Chronic obstructive pulmonary disease (COPD)

Bronchospasm relief

Adjunct therapy in respiratory disorders

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Doxofylline

Tablet

Doxofylline is a xanthine derivative with bronchodilator properties. It improves airflow by relaxing bronchial smooth muscles, reducing airway resistance, and enhancing oxygenation. Compared to theophylline, Doxofylline has fewer cardiovascular and gastrointestinal side effects, making it a safer option in long-term respiratory therapy.

Speciality	Respiratory / Bronchodilator
Tags	Asthma \| COPD \| Bronchodilator
Strength	400 mg
Packing Size	10 Tablets

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Mechanism

Doxofylline inhibits phosphodiesterase enzymes, increasing cyclic AMP levels in bronchial smooth muscle. This leads to relaxation of airways, improved airflow, and reduced bronchospasm. Unlike theophylline, it has minimal cardiac stimulation and reduced gastrointestinal irritation.

Pharmacokinetics

Absorption: Rapid oral absorption
Distribution: Widely distributed in lung tissues
Metabolism: Hepatic metabolism
Elimination: Renal excretion
Half-life: ≈ 6–8 hours

Side Effects

Nausea
Headache
Insomnia
Rare: palpitations

Contraindication

Hypersensitivity to xanthine derivatives
Severe hepatic impairment

Interaction

Beta-agonists — additive bronchodilation
Corticosteroids — synergistic effect in asthma/COPD
Alcohol — may enhance CNS stimulation
Other xanthines — increased risk of side effects

Warning and Precautions

Monitor liver function during therapy
Use cautiously in patients with cardiovascular disease
Avoid excessive caffeine intake