Doxofylline + Montelukast Tablets

Therapeutic Indication

Asthma management

Chronic obstructive pulmonary disease (COPD)

Bronchospasm relief

Adjunct therapy in allergic airway disorders

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Doxofylline + Montelukast

Tablet

This fixed-dose combination provides dual benefits in respiratory care. Doxofylline, a xanthine derivative, acts as a bronchodilator with fewer side effects compared to theophylline. Montelukast, a leukotriene receptor antagonist, reduces airway inflammation and prevents bronchoconstriction. Together, they improve airflow, reduce symptoms, and enhance quality of life in asthma and COPD patients.

Speciality	Respiratory / Combination Therapy
Tags	Asthma \| COPD \| Bronchodilator \| Anti-inflammatory
Strength	Doxofylline 400 mg Montelukast 10 mg
Packing Size	10 Tablets

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Mechanism

Doxofylline inhibits phosphodiesterase enzymes, increasing cyclic AMP levels in bronchial smooth muscle, leading to airway relaxation. Montelukast blocks leukotriene D4 receptors, reducing inflammation, mucus secretion, and bronchoconstriction. The combination provides synergistic control of airway obstruction and inflammation.

Pharmacokinetics

Doxofylline Absorption: Rapid oral absorption
Doxofylline Half-life: ≈ 6–8 hours
Montelukast Absorption: Rapid oral absorption, bioavailability ≈ 64%
Montelukast Half-life: ≈ 2.7–5.5 hours
Elimination: Both drugs undergo hepatic metabolism and renal/fecal excretion

Side Effects

Nausea
Headache
Insomnia
Abdominal discomfort
Rare: palpitations, mood changes

Contraindication

Hypersensitivity to xanthine derivatives or Montelukast
Severe hepatic impairment

Interaction

Doxofylline — interacts with beta-agonists, corticosteroids, alcohol, and other xanthines
Montelukast — interacts with CYP3A4 inducers (rifampicin, phenytoin) reducing efficacy
Use cautiously with hepatotoxic drugs

Warning and Precautions

Monitor liver function during therapy
Use cautiously in patients with cardiovascular disease
Not recommended for acute asthma attacks (maintenance therapy only)