Cold & Flu Relief Tablets

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Therapeutic Indication

Mixed bacterial and protozoal infections
Gastrointestinal infections
Respiratory tract infections
Urinary tract infections
Gynecological infections
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Diphenhydramine + Phenylephrine + Caffeine + Paracetamol

Tablet

This combination tablet provides symptomatic relief from cold, flu, headache, nasal congestion, and fever. It combines antihistamine, decongestant, analgesic, and stimulant actions.

Speciality General Medicine | ENT | Internal Medicine
Tags Cold Relief | Flu | Headache | Fever | Nasal Congestion
Strength
  • Phenylephrine 5 mg
  • Diphenhydramine 25 mg
  • Caffeine (Anhydrous) 30 mg
  • Paracetamol 500 mg
Packing Size
  • 10 Tablets

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Mechanism

Diphenhydramine: Antihistamine that reduces allergy symptoms and provides sedation.
Phenylephrine: Decongestant that constricts nasal blood vessels, relieving congestion.
Caffeine: CNS stimulant that reduces fatigue and enhances analgesic effect.
Paracetamol: Analgesic and antipyretic that reduces pain and fever.

Pharmacokinetics

  • Diphenhydramine: Rapidly absorbed; peak plasma concentration in 2–3 hours; metabolized in liver (CYP2D6); half-life ~4–8 hours; excreted in urine.
  • Phenylephrine: Low oral bioavailability (~40%); peak effect within 1–2 hours; metabolized extensively in gut and liver; half-life ~2–3 hours.
  • Caffeine: Almost completely absorbed; peak plasma concentration in 30–60 minutes; metabolized in liver (CYP1A2); half-life ~3–7 hours; excreted in urine.
  • Paracetamol: Rapid absorption; peak plasma concentration in 30–60 minutes; metabolized in liver (glucuronidation, sulfation); half-life ~2–3 hours; excreted in urine.

Side Effects

  • Drowsiness (due to Diphenhydramine)
  • Insomnia or jitteriness (due to Caffeine)
  • Increased blood pressure (due to Phenylephrine)
  • Nausea, liver toxicity (rare, due to Paracetamol overdose)

Contraindication

  • Severe hypertension or heart disease
  • Liver impairment
  • Hypersensitivity to any component
  • Children under 12 years (unless prescribed)

Interaction

  • Alcohol (increases sedation and liver risk)
  • MAO inhibitors (dangerous with Phenylephrine)
  • Other hepatotoxic drugs (increase Paracetamol risk)

Warning and Precautions

  • Use under medical supervision only
  • Do not exceed recommended dosage
  • Monitor blood pressure in hypertensive patients
  • Avoid alcohol during therapy

Dosage

As directed by the Physician.

Disclaimer

All product details on this website are for reference and informational purposes only and are not directed at patients or consumers.
As a contract manufacturer, DM Pharma Pvt Ltd is not responsible for the marketing or end use of these products and disclaims all liability arising from reliance on this information.
Please consult a healthcare professional before using any medicinal product.