Diloxanide + Ornidazole + Simethicone Tablets

Therapeutic Indication

Amoebiasis

Giardiasis

Mixed intestinal protozoal infections

Relief of bloating and gas-related discomfort

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Diloxanide + Ornidazole + Simethicone

Tablet

Diloxanide acts as a luminal amoebicide, Ornidazole is a nitroimidazole derivative effective against protozoa and anaerobic bacteria, and Simethicone reduces bloating by breaking down gas bubbles in the gastrointestinal tract.

Speciality	Gastroenterology \| Internal Medicine \| Infectious Diseases
Tags	Anti-amoebic \| Antiprotozoal \| Antibacterial \| Anti-gas
Strength	Diloxanide 375 mg Ornidazole 250 mg Simethicone 25 mg
Packing Size	10 Tablets

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Mechanism

Diloxanide eliminates parasites from the intestinal lumen. Ornidazole disrupts protozoal DNA synthesis. Simethicone reduces gas bubbles, relieving bloating.

Pharmacokinetics

Absorption: Ornidazole well absorbed orally; Diloxanide acts locally; Simethicone not absorbed.
Metabolism: Ornidazole metabolized hepatically; Diloxanide partly metabolized; Simethicone inert.
Excretion: Ornidazole via urine; Diloxanide via urine; Simethicone excreted unchanged.

Side Effects

Nausea
Metallic taste
Dizziness
Headache
Mild gastrointestinal discomfort

Contraindication

Hypersensitivity to any component
Pregnancy (unless essential)
Severe hepatic impairment

Interaction

Alcohol (disulfiram-like reaction with Ornidazole)
Anticoagulants (enhanced effect)

Warning and Precautions

Use only under physician guidance
Monitor for neurological side effects with prolonged use
Not recommended during pregnancy unless essential

Dosage

As directed by the Physician.