Dienogest Tablets

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Therapeutic Indication

Treatment of endometriosis
Reduction of pelvic pain
Management of abnormal uterine bleeding
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Dienogest

Tablet

Dienogest is a synthetic progestin used primarily for the treatment of endometriosis. It works by suppressing estrogen production, thereby reducing the growth of endometrial tissue. This helps in relieving pelvic pain, inflammation, and other symptoms associated with endometriosis.

Speciality Gynaecology
Tags Women Health | Endometriosis
Strength
  • 2 mg
Packing Size
  • 10 Tablets

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Mechanism

Dienogest acts as a progestin that suppresses estrogen levels and inhibits the growth of endometrial tissue. It reduces inflammation and prevents the progression of endometriosis.

Pharmacokinetics

  • Absorption: Dienogest is rapidly and almost completely absorbed after oral administration. Peak plasma concentrations are reached within 1.5 hours.
  • Distribution: Dienogest is moderately bound to plasma proteins (about 90%) and does not bind specifically to sex hormone-binding globulin (SHBG). It is widely distributed in body tissues.
  • Metabolism: Dienogest is extensively metabolized in the liver, mainly via hydroxylation and conjugation pathways, producing inactive metabolites.
  • Elimination: Dienogest is excreted primarily in the form of metabolites via urine and feces. The elimination half-life is approximately 9–10 hours.
  • Special Populations:
    • Hepatic impairment: Use is contraindicated in severe liver disease.
    • Renal impairment: No significant effect on pharmacokinetics.

Side Effects

  • Headache
  • Breast discomfort
  • Mood changes
  • Acne
  • Irregular menstrual bleeding

Contraindication

  • Pregnancy
  • Severe liver disease
  • History of thromboembolic disorders

Interaction

  • Antiepileptic drugs
  • Rifampicin and enzyme inducers
  • Hormonal therapies

Warning and Precautions

  • Use under medical supervision
  • Not recommended during pregnancy
  • Monitor menstrual irregularities
  • Caution in liver disorders

Dosage

As directed by the Physician.