Dicyclomine + Mefenamic Tablets

Mechanism

Dicyclomine: Anticholinergic agent that relaxes smooth muscle in the gastrointestinal tract, reducing spasms and pain. Mefenamic Acid: NSAID that inhibits prostaglandin synthesis, providing analgesic, anti-inflammatory, and antipyretic effects.

Pharmacokinetics

• Absorption: Both drugs are well absorbed orally.
• Distribution: Dicyclomine widely distributed; Mefenamic Acid ~90% protein bound.
• Metabolism: Dicyclomine metabolized hepatically; Mefenamic Acid metabolized in liver via CYP2C9.
• Elimination: Dicyclomine excreted in urine/feces; Mefenamic Acid mainly via urine.
• Half-life: Dicyclomine ≈ 1.8 hours; Mefenamic Acid ≈ 2 hours.

Side Effects

• Drowsiness, dizziness
• Dry mouth, blurred vision
• Nausea, vomiting
• Abdominal discomfort
• Rare: hypersensitivity reactions

Contraindication

• Hypersensitivity to Dicyclomine, Mefenamic Acid, or excipients
• Glaucoma, myasthenia gravis (Dicyclomine contraindicated)
• Peptic ulcer disease, GI bleeding (Mefenamic Acid contraindicated)
• Severe hepatic or renal impairment
• Pregnancy and lactation — use cautiously

Interaction

• Anticholinergics: Additive effects with Dicyclomine.
• NSAIDs / Anticoagulants: Increased risk of GI bleeding with Mefenamic Acid.
• CYP2C9 inhibitors: May increase plasma levels of Mefenamic Acid.
• Alcohol: May enhance CNS side effects and GI irritation.

Warning and Precautions

• Monitor liver and renal function during therapy.
• Use cautiously in elderly patients due to anticholinergic effects.
• Discontinue if severe GI bleeding or hypersensitivity occurs.
• Avoid driving or operating machinery if drowsy.