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Diclofenac + Thiocolchicoside Tablets

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Therapeutic Indication

Musculoskeletal pain
Inflammation and swelling
Muscle spasms (back pain, neck pain)
Arthritis and joint pain
+91 85919 78885

Diclofenac + Thiocolchicoside

Tablet

Diclofenac sodium is a non steroidal anti - inflammatory drug that helps relieve pain, stiffness, and swelling caused by several types of arthritis, including osteoarthritis and rheumatoid arthritis. Thiocolchicoside (THC) is used clinically for its muscle relaxant, anti-inflammatory, and analgesic properties, and it has been shown to interact with g-amino butyric acid (GABA) type a receptors (GABAARs) and strychnine sensitive Glycine receptors in the rat central nervous system. It acts as a competitive GABAA receptor antagonist and also inhibits glycine receptors with similar potency and nicotinic acetylcholine receptors to a much lesser extent. It has powerful convulsant activity and should not be used in seizureprone individuals.

Speciality Orthopedics | Pain Management | Rheumatology
Tags Joint Care | Immunity Booster
Strength
  • Diclofenac 50 mg
  • Thiocolchicoside 4 mg/8 mg
Packing Size
  • 10 Tablets

Check all Tablets Range

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Mechanism

Diclofenac inhibits prostaglandin synthesis, reducing inflammation and pain. Thiocolchicoside acts on GABA receptors, relaxing skeletal muscles and reducing spasms.

Pharmacokinetics

  • Absorption: Rapid oral absorption.
  • Distribution: Widely distributed.
  • Metabolism: Hepatic metabolism.
  • Elimination: Renal and fecal excretion.
  • Half-life: Diclofenac ~1–2 hrs; Thiocolchicoside ~5–6 hrs.

Side Effects

  • Gastric irritation, nausea
  • Drowsiness, diarrhea
  • Rare: liver toxicity

Contraindication

  • Severe liver or kidney disease
  • History of gastric ulcers
  • Pregnancy & breastfeeding (Thiocolchicoside contraindicated)
  • Hypersensitivity to NSAIDs

Interaction

  • Alcohol: Increases risk of gastric bleeding and liver damage.
  • Anticoagulants: Diclofenac may enhance bleeding risk.
  • Other NSAIDs: Avoid duplication of therapy.

Warning and Precautions

  • Do not exceed recommended dose.
  • Use cautiously in patients with GI disorders.
  • Monitor liver function during prolonged use.