Diclofenac + Paracetamol + Serratiopeptidase Tablets

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Therapeutic Indication

Musculoskeletal pain and inflammation
Post-surgical swelling and pain
Arthritis and joint stiffness
Soft tissue injuries and trauma
Fever reduction
Dental pain and swelling
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Diclofenac + Paracetamol + Serratiopeptidase

Tablet

This triple combination provides comprehensive therapy: Diclofenac reduces pain and inflammation, Paracetamol lowers fever and enhances analgesia, while Serratiopeptidase enzymatically reduces swelling and accelerates healing.

Speciality Orthopedics | Dentistry | General Medicine
Tags Pain Relief | Anti-inflammatory | Enzyme Therapy | Fever Reduction
Strength
  • Diclofenac Potassium 50 mg
  • Paracetamol 325 mg
  • Serratiopeptidase 10 mg
Packing Size
  • 10 Tablets

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Mechanism

  • Diclofenac: Inhibits cyclooxygenase enzymes, reducing prostaglandin synthesis → anti-inflammatory and analgesic effect.
  • Paracetamol: Acts centrally to reduce fever and pain via inhibition of brain prostaglandins.
  • Serratiopeptidase: Breaks down inflammatory mediators and fibrin deposits → reduces edema and accelerates healing.

Pharmacokinetics

  • Diclofenac: Rapid absorption, >99% plasma protein binding, half-life 1–2 hrs.
  • Paracetamol: Peak plasma 10–60 min, widely distributed, weak anti-inflammatory.
  • Serratiopeptidase: Absorbed via intestinal mucosa, functional activity ~6–8 hrs.

Side Effects

  • GI upset, nausea, headache
  • Dizziness
  • Rare allergic reactions

Contraindication

  • Hypersensitivity to Diclofenac, Paracetamol, or Serratiopeptidase
  • Pregnancy & lactation (not recommended)
  • Severe hepatic impairment

Interaction

  • Diclofenac: Increases plasma levels of lithium, digoxin, methotrexate; enhances anticoagulant activity.
  • Paracetamol: Risk of hepatotoxicity with rifampicin, isoniazid, chloramphenicol, antiepileptics, antivirals.
  • Serratiopeptidase: May enhance effects of anticoagulants and antiplatelet drugs.

Warning and Precautions

  • Monitor liver function during prolonged therapy.
  • Use with caution in renal impairment.
  • Avoid alcohol due to hepatotoxicity risk.

Dosage

As directed by the Physician.