Diclofenac + Misoprostol Tablets

Project Image
Thumb Image
Thumb Image
Thumb Image
Thumb Image

Therapeutic Indication

Rheumatoid arthritis
Osteoarthritis
Ankylosing spondylitis
Pain relief with gastric protection
+91 85919 78885

Diclofenac + Misoprostol

Tablet

A combination of Diclofenac Sodium, a potent NSAID, with Misoprostol, a synthetic prostaglandin analog, designed to relieve arthritis pain while reducing the risk of NSAID-induced gastric ulcers.

Speciality Orthopedics | Rheumatology | Internal Medicine
Tags Arthritis | Pain Relief | Gastric Protection | NSAID
Strength
  • Diclofenac Sodium (Enteric Coated) 50 mg
  • Misoprostol 200 mcg
Packing Size
  • 10 Tablets

Check all Tablets Range

Click to know More

Mechanism

  • Diclofenac: Inhibits prostaglandin synthesis, reducing inflammation, pain, and fever.
  • Misoprostol: Stimulates gastric mucus and bicarbonate secretion, protecting stomach lining.
  • Combination: Provides effective pain relief with reduced risk of gastric ulcers.

Pharmacokinetics

  • Absorption: Diclofenac absorbed in intestine; Misoprostol rapidly absorbed orally.
  • Distribution: Diclofenac binds plasma proteins; Misoprostol distributed in GI mucosa.
  • Metabolism: Diclofenac metabolized in liver; Misoprostol converted to active metabolite.
  • Excretion: Primarily via urine and feces.

Side Effects

  • Abdominal pain
  • Diarrhea
  • Nausea
  • Dyspepsia

Contraindication

  • Pregnancy (Misoprostol may cause miscarriage)
  • Hypersensitivity to NSAIDs or prostaglandins
  • Severe hepatic or renal impairment

Interaction

  • Other NSAIDs increase GI risk.
  • Antihypertensives may have reduced efficacy.
  • Anticoagulants increase bleeding risk.

Warning and Precautions

  • Use under medical supervision in elderly patients.
  • Monitor liver and kidney function during therapy.
  • Do not exceed recommended dosage.

Dosage

As directed by the Physician.