Diclofenac + Metaxalone Tablets

Mechanism

Diclofenac potassium is a non-steroidal anti-inflammatory drug (NSAID). The mechanism of action like that of other NSAIDs, is not completely understood but may be related to prostaglandin synthetase inhibition. Diclofenac works by blocking the effect of chemicals in your body, called cyclo-oxygenase (COX) enzymes. These enzymes help to make other chemicals in the body, called prostaglandins. Prostaglandins are produced at sites of injury or damage, and cause pain and inflammation. By blocking the effect of COX enzymes, fewer prostaglandins are produced, which means pain and inflammation are eased. The mechanism of action of metaxalone in humans has not been established, but may be due to general central nervous system depression. Metaxalone has no direct action on the contractile mechanism of striated muscle, the motor end plate, or the nerve fiber.

• Diclofenac: Inhibits prostaglandin synthesis, reducing inflammation and pain.
• Metaxalone: Acts on the central nervous system to relax skeletal muscles and relieve spasms.
• Combination: Provides synergistic relief in musculoskeletal pain conditions.

Pharmacokinetics

• Absorption: Diclofenac absorbed in intestine; Metaxalone absorbed orally.
• Distribution: Widely distributed in plasma and tissues.
• Metabolism: Diclofenac metabolized in liver; Metaxalone metabolized hepatically.
• Excretion: Primarily via urine and feces.

Side Effects

• Drowsiness, dizziness
• Abdominal pain, nausea
• Headache
• Rare allergic reactions

Contraindication

• Hypersensitivity to NSAIDs or muscle relaxants
• Severe hepatic impairment
• Pregnancy & lactation (use under medical supervision)

Interaction

• Alcohol enhances CNS depressant effects of Metaxalone.
• Other NSAIDs increase GI risk.
• Anticoagulants increase bleeding risk.

Warning and Precautions

• Use with caution in patients with liver disease.
• Monitor for GI bleeding during therapy.
• Avoid alcohol and CNS depressants.

Dosage

As directed by the Physician.