Desvenlafaxine Tablets

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Therapeutic Indication

Major Depressive Disorder (MDD)
Generalized Anxiety Disorder
Neuropathic pain (including diabetic neuropathy)
Fibromyalgia and chronic pain syndromes
Off-label: menopausal hot flashes
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Desvenlafaxine

Tablet

Desvenlafaxine is a serotonin–norepinephrine reuptake inhibitor (SNRI) used to treat depression, anxiety, and certain pain conditions. It improves mood balance by increasing serotonin and norepinephrine levels in the brain, while also reducing pain signaling.

Speciality Psychiatry | Neurology | Pain Medicine | General Medicine
Tags SNRI | Antidepressant | Anxiety Relief | Neuropathic Pain
Strength
  • 50 mg (Extended Release)
  • 100 mg (Extended Release)
Packing Size
  • 10 Tablets

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Mechanism

Desvenlafaxine inhibits the reuptake of serotonin and norepinephrine in the central nervous system. This increases neurotransmitter levels in synaptic clefts, improving mood regulation and reducing pain perception.

Pharmacokinetics

  • Absorption: Well absorbed orally; extended-release formulation ensures steady plasma levels.
  • Distribution: Widely distributed; moderate protein binding (~30%).
  • Metabolism: Minimal hepatic metabolism; primarily conjugated.
  • Excretion: ~45% excreted unchanged in urine.
  • Half-life: ~11 hours (supports once-daily dosing).

Side Effects

  • Nausea
  • Dizziness
  • Insomnia
  • Dry mouth
  • Fatigue
  • Serotonin syndrome (rare, serious)

Contraindication

  • Hypersensitivity to desvenlafaxine
  • Concurrent use with MAO inhibitors
  • Severe renal or hepatic impairment

Interaction

  • Alcohol (increases CNS depression)
  • Other serotonergic drugs (risk of serotonin syndrome)
  • Anticoagulants/NSAIDs (increased bleeding risk)

Warning and Precautions

  • Use under medical supervision only
  • Monitor mood changes and suicidal ideation
  • Caution in patients with cardiac arrhythmias

Dosage

As directed by the Physician.