Desmopressin Tablets

Therapeutic Indication

Central Diabetes Insipidus

Nocturnal Enuresis (bed-wetting)

Nocturia (night-time urination)

Bleeding disorders (Hemophilia A, Von Willebrand’s disease type I)

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Desmopressin

Tablet

Desmopressin is a synthetic analogue of vasopressin (antidiuretic hormone). It reduces urine production by increasing water reabsorption in the kidneys. It is used under medical supervision due to the risk of hyponatremia (low sodium levels).

Speciality	Endocrinology \| Nephrology \| Hematology
Tags	Antidiuretic \| Bed-wetting \| Bleeding Disorders
Strength	0.1 mg 0.2 mg
Packing Size	10 Tablets

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Mechanism

Desmopressin acts on renal collecting ducts to increase water reabsorption, reducing urine output. It also increases plasma levels of clotting factors in certain bleeding disorders.

Pharmacokinetics

Absorption: Oral bioavailability ~5%.
Distribution: Widely distributed; does not cross blood-brain barrier significantly.
Metabolism: Minimal hepatic metabolism.
Elimination: Primarily renal excretion.
Half-life: ~2–3 hours.

Side Effects

Headache
Nausea
Dizziness
Hyponatremia (low sodium)
Seizures (rare)

Contraindication

Severe kidney disease
Hyponatremia
Heart failure
Hypersensitivity to desmopressin

Interaction

NSAIDs (increase risk of hyponatremia)
Antidepressants (SSRIs, TCAs – risk of low sodium)
Carbamazepine (enhanced antidiuretic effect)

Warning and Precautions

Monitor serum sodium regularly
Restrict fluid intake during therapy
Use under strict medical supervision

Dosage

As directed by the Physician.

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Please consult a healthcare professional before using any medicinal product.