Desloratadine Tablets

Therapeutic Indication

Allergic rhinitis (seasonal & perennial)

Chronic idiopathic urticaria

Relief of sneezing, runny nose, itchy/watery eyes

Relief of hives and skin allergy symptoms

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Desloratadine

Tablet

Desloratadine is a non-sedating, long-acting antihistamine. It selectively blocks peripheral histamine H1 receptors, reducing allergic symptoms without significant penetration into the central nervous system.

Speciality	Antihistamine \| Allergy Relief
Tags	Allergy \| Antihistamine \| Rhinitis \| Urticaria
Strength	5 mg
Packing Size	10 Tablets

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Mechanism

Desloratadine selectively blocks histamine H1 receptors in peripheral tissues. This prevents histamine-mediated allergic responses such as sneezing, itching, watery eyes, and hives, without causing sedation.

Pharmacokinetics

Absorption: Rapid oral absorption.
Distribution: Widely distributed; minimal CNS penetration.
Metabolism: Hepatic metabolism via CYP3A4 and CYP2D6.
Elimination: Renal and fecal excretion.
Half-life: Approximately 27 hours.

Side Effects

Headache
Dry mouth
Fatigue
Rare: tachycardia, hypersensitivity reactions

Contraindication

Hypersensitivity to Desloratadine or Loratadine
Severe hepatic impairment

Interaction

Ketoconazole, Erythromycin, Azithromycin: May increase plasma levels of Desloratadine.
Other antihistamines: Possible additive effects.

Warning and Precautions

Use cautiously in patients with renal impairment.
Not recommended for children under 12 years without medical advice.
Monitor for hypersensitivity reactions.