Desloratadine Tablets 5 mg | Uses, Dosage, Side Effects, Anti-Epileptic Drug

Therapeutic Indication

Seasonal allergic rhinitis (hay fever)

Perennial allergic rhinitis

Chronic idiopathic urticaria (hives)

Relief of sneezing, runny nose, itchy/watery eyes

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Desloratadine

Tablet

Desloratadine is a long-acting, non-sedating antihistamine. It selectively blocks peripheral histamine H1 receptors, reducing allergic symptoms without crossing the blood-brain barrier significantly. It is widely prescribed for allergic rhinitis and chronic urticaria.

Speciality	Non-sedating Antihistamine
Tags	Antihistamine \| Allergy Relief \| Urticaria \| Rhinitis
Strength	5 mg
Packing Size	10 Tablets

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Mechanism

Desloratadine blocks histamine H1 receptors, preventing histamine from binding and triggering allergic responses. This reduces sneezing, itching, watery eyes, and hives without causing significant drowsiness.

Pharmacokinetics

Absorption: Rapid oral absorption
Distribution: Widely distributed, minimal CNS penetration
Metabolism: Hepatic metabolism via CYP3A4 and CYP2D6
Elimination: Renal and fecal excretion
Half-life: 27 hours (long-acting)

Side Effects

Headache
Dry mouth
Fatigue
Rare: tachycardia, hypersensitivity reactions

Contraindication

Hypersensitivity to Desloratadine or Loratadine
Severe hepatic impairment

Interaction

Ketoconazole, erythromycin, and azithromycin (may increase plasma levels)
Alcohol and CNS depressants (no significant interaction, but caution advised)
Other antihistamines (additive effects possible)

Warning and Precautions

Use cautiously in patients with renal impairment
Monitor for allergic reactions
Not recommended for children under 12 years without medical advice