Deflazacort Tablets

Mechanism

Deflazacort is a glucocorticoid that enters cells, binds to cytoplasmic receptors, and alters gene transcription to suppress pro‑inflammatory cytokines and immune mediators. This reduces inflammation, modulates immune responses, and decreases circulating white blood cells. Clinically, it helps control allergic and inflammatory conditions (asthma, arthritis), prevents transplant rejection, and is useful in certain leukemias and autoimmune diseases.

Pharmacokinetics

• Absorption: Rapid oral absorption; food may slightly delay peak concentration.
• Bioavailability: ~90% for active metabolite (21‑desacetyl deflazacort).
• Time to Peak (Tmax): 1–2 hours after oral dose.
• Distribution: ~40% protein bound; widely distributed in tissues.
• Metabolism: Rapidly converted by esterases to active metabolite; further metabolized via CYP3A4.
• Elimination Half‑life: ~1.1–1.9 hours for active metabolite.
• Excretion: Primarily urinary (~68–70%), remainder via feces.

Side Effects

• Weight gain
• Increased appetite
• Mood changes
• Stomach discomfort

Contraindication

• Systemic fungal infections
• Hypersensitivity to corticosteroids

Interaction

• NSAIDs
• Antidiabetic drugs
• Vaccines

Warning and Precautions

This has been prescribed for the patient's specific condition. It may be dangerous to any other person.

• Do not stop abruptly
• Use under medical supervision
• Caution in diabetes and hypertension
• Consult doctor during pregnancy

Dosage

As directed by the Physician.