Deferasirox Tablets

Vildagliptin Tablet

Therapeutic Indication

Chronic iron overload due to blood transfusions
Non-transfusion-dependent thalassemia with high liver iron
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Deferasirox

Tablet

Deferasirox is an oral iron chelator that binds excess iron, allowing it to be excreted. It is used to manage chronic iron overload in patients receiving long-term blood transfusions and in certain thalassemia cases.

Speciality Hematology | Internal Medicine
Tags Iron Chelator | Antithalassemia
Strength
  • 100 mg
  • 400 mg
Packing Size
  • 10 Tablets

Check all Tablets Range

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Mechanism

Deferasirox binds excess iron in the bloodstream and tissues, forming complexes that are excreted primarily via feces.

Pharmacokinetics

  • Absorption: Oral, peak plasma in 1.5–4 hours
  • Metabolism: Hepatic glucuronidation
  • Elimination: Fecal excretion
  • Half-life: 8–16 hours

Side Effects

  • Nausea, vomiting, diarrhea
  • Abdominal pain
  • Skin rash
  • Rare: Renal or hepatic impairment, GI bleeding

Contraindication

  • Severe renal impairment (eGFR < 40 mL/min/1.73 m²)
  • Severe hepatic impairment
  • Platelet count < 50 × 10⁹/L

Interaction

  • Concomitant nephrotoxic drugs
  • CYP inducers/inhibitors may alter levels

Warning and Precautions

  • Monitor renal and hepatic function regularly
  • Discontinue if severe GI bleeding occurs
  • Adjust dose based on ferritin and liver iron concentration

Dosage

As directed by the Physician.